Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

FH tetramer hydrates fumarate to L-malate

FUMA + H2O → MAL

Reactome: R-HSA-70982
Compartment: mitochondrial matrix
Rhea: RHEA:12462, RHEA:12460

Inputs

FUMACHEBI:29806, C4H2O4, mitochondrial matrix
H2OCHEBI:15377, H2O, mitochondrial matrix

Outputs

MALCHEBI:15589, C4H4O5, mitochondrial matrix

Catalysed by

fumarate hydratase activity of FH tetramer [mitochondrial matrix]EC 4.2.1.2

FH tetramer hydrates fumarate to L-malate

Inputs

Outputs

Catalysed by

Literature