CS acetylates OA to citrate
Ac-CoA + H2O + OA → CIT + CoA-SH + H+
- Reactome
- R-HSA-70975
- Compartment
- mitochondrial matrix
- Rhea
- RHEA:16846
Inputs
- Ac-CoACHEBI:57288, C23H34N7O17P3S, mitochondrial matrix
- H2OCHEBI:15377, H2O, mitochondrial matrix
- OACHEBI:16452, C4H2O5, mitochondrial matrix
Outputs
- CITCHEBI:16947, C6H5O7, mitochondrial matrix
- CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix
- H+CHEBI:15378, H, mitochondrial matrix
Catalysed by
- citrate synthase activity of N6,N6,N6-trimethyl-K395-CS dimer [mitochondrial matrix]EC 2.3.3.1
Literature
- Complexes between mitochondrial enzymes and either citrate synthase or glutamate dehydrogenase Arch Biochem Biophys, 1983
- Cloning and molecular analysis of the human citrate synthase gene Genome, 1998
- Uncovering human METTL12 as a mitochondrial methyltransferase that modulates citrate synthase activity through metabolite-sensitive lysine methylation J Biol Chem, 2017
- Interaction between citrate synthase and malate dehydrogenase. Substrate channeling of oxaloacetate J Biol Chem, 1998
- Association of the malate dehydrogenase-citrate synthase metabolon is modulated by intermediates of the Krebs tricarboxylic acid cycle Sci Rep, 2021
- Krebs cycle metabolon: structural evidence of substrate channeling revealed by cross-linking and mass spectrometry Angew Chem Int Ed Engl, 2015