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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ACO2 isomerizes citrate

CIT → ISCIT

Reactome: R-HSA-70971
Compartment: mitochondrial matrix
Rhea: RHEA:10337, RHEA:10336

Inputs

CITCHEBI:16947, C6H5O7, mitochondrial matrix

Outputs

ISCITCHEBI:15562, C6H5O7, mitochondrial matrix

Catalysed by

aconitate hydratase activity of ACO2:4Fe-4S [mitochondrial matrix]EC 4.2.1.3

Literature

Purification and partial amino acid sequence of human aconitase Protein Seq Data Anal, 1991
Aconitase polymorphism in man Ann Hum Genet, 1975
ACO2 clinicobiological dataset with extensive phenotype ontology annotation Sci Data, 2021