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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

IDH3 complex decarboxylates isocitrate

ISCIT + NAD+ → 2OG + CO2 + NADH

Reactome: R-HSA-70967
Compartment: mitochondrial matrix
Rhea: RHEA:23633

Inputs

ISCITCHEBI:15562, C6H5O7, mitochondrial matrix
NAD+CHEBI:57540, C21H26N7O14P2, mitochondrial matrix

Outputs

2OGCHEBI:16810, C5H4O5, mitochondrial matrix
CO2CHEBI:16526, CO2, mitochondrial matrix
NADHCHEBI:57945, C21H27N7O14P2, mitochondrial matrix

Catalysed by

isocitrate dehydrogenase (NAD+) activity of IDH3 octamer [mitochondrial matrix]EC 1.1.1.41

Literature