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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

beta-hydroxyisobutyrate + NAD+ methylmalonyl semialdehyde + NADH + H+

bHIBA + NAD+ → 2M3OPROA + NADH + H+

Reactome: R-HSA-70885
Compartment: mitochondrial matrix
Rhea: RHEA:31276

Inputs

bHIBACHEBI:62638, C4H7O3, mitochondrial matrix
NAD+CHEBI:57540, C21H26N7O14P2, mitochondrial matrix

Outputs

2M3OPROACHEBI:62413, C4H5O3, mitochondrial matrix
NADHCHEBI:57945, C21H27N7O14P2, mitochondrial matrix
H+CHEBI:15378, H, mitochondrial matrix

Catalysed by

3-hydroxyisobutyrate dehydrogenase activity of HIBADH tetramer [mitochondrial matrix]EC 1.1.1.31

Literature

Purification and properties of beta-hydroxyisobutyric dehydrogenase J Biol Chem, 1957