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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA

bHIB-CoA + H2O → bHIBA + CoA-SH + H+

Reactome: R-HSA-70881
Compartment: mitochondrial matrix
Rhea: RHEA:31252

Inputs

bHIB-CoACHEBI:62611, C25H38N7O18P3S, mitochondrial matrix
H2OCHEBI:15377, H2O, mitochondrial matrix

Outputs

bHIBACHEBI:62638, C4H7O3, mitochondrial matrix
CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix
H+CHEBI:15378, H, mitochondrial matrix

Catalysed by

3-hydroxyisobutyryl-CoA hydrolase activity of HIBCH [mitochondrial matrix]EC 3.1.2.4; UniProt Q6NVY1

Literature

Primary structure and tissue-specific expression of human beta-hydroxyisobutyryl-coenzyme A hydrolase. J Biol Chem, 1996