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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

alpha-methylacetoacetyl-CoA + CoA => propionyl-CoA + acetyl-CoA

2MACA-CoA + CoA-SH → PROP-CoA + Ac-CoA

Reactome: R-HSA-70844
Compartment: mitochondrial matrix
Rhea: RHEA:30721

Inputs

2MACA-CoACHEBI:57335, C26H38N7O18P3S, mitochondrial matrix
CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix

Outputs

PROP-CoACHEBI:57392, C24H36N7O17P3S, mitochondrial matrix
Ac-CoACHEBI:57288, C23H34N7O17P3S, mitochondrial matrix

Catalysed by

acetyl-CoA C-acetyltransferase activity of ACAT1 tetramer [mitochondrial matrix]EC 2.3.1.9

Literature

Crystallographic and kinetic studies of human mitochondrial acetoacetyl-CoA thiolase: the importance of potassium and chloride ions for its structure and function Biochemistry, 2007