leu, ile, or val + alpha-ketoglutarate a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate [BCAT2]
Leu, Ile, Val + 2OG → KIC, KMVA, KIV + L-Glu
- Reactome
- R-HSA-70724
- Compartment
- mitochondrial matrix
- Rhea
- RHEA:24814, RHEA:18322, RHEA:24802
Inputs
- Leu, Ile, ValR-ALL-508190, mitochondrial matrix
- 2OGCHEBI:16810, C5H4O5, mitochondrial matrix
Outputs
- KIC, KMVA, KIVR-ALL-508181, mitochondrial matrix
- L-GluCHEBI:29985, C5H8NO4, mitochondrial matrix
Catalysed by
- branched-chain-amino-acid:2-oxoglutarate transaminase activity of BCAT2 dimer [mitochondrial matrix]EC 2.6.1.42
Literature
- Cloning of the rat and human mitochondrial branched chain aminotransferases (BCATm) Biochim Biophys Acta, 1997
- The structure of human mitochondrial branched-chain aminotransferase. Acta Crystallogr D Biol Crystallogr, 2001
- Crystal structures of human mitochondrial branched chain aminotransferase reaction intermediates: ketimine and pyridoxamine phosphate forms Biochemistry, 2002