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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

argininosuccinate fumarate + arginine

ARSUA → L-Arg + FUMA

Reactome: R-HSA-70573
Compartment: cytosol
Rhea: RHEA:24021

Inputs

ARSUACHEBI:57472, C10H17N4O6, cytosol

Outputs

L-ArgCHEBI:32682, C6H15N4O2, cytosol
FUMACHEBI:29806, C4H2O4, cytosol

Catalysed by

argininosuccinate lyase activity of ASL tetramer [cytosol]EC 4.3.2.1

Literature

Human argininosuccinate lyase: a structural basis for intragenic complementation Proc Natl Acad Sci U S A, 1997
Molecular analysis of human argininosuccinate lyase: mutant characterization and alternative splicing of the coding region Proc Natl Acad Sci U S A, 1990