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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

arginine + H2O => ornithine + urea [ARG1]

L-Arg + H2O → L-Orn + Urea

Reactome: R-HSA-70569
Compartment: cytosol
Rhea: RHEA:20570

Inputs

L-ArgCHEBI:32682, C6H15N4O2, cytosol
H2OCHEBI:15377, H2O, cytosol

Outputs

L-OrnCHEBI:46911, C5H13N2O2, cytosol
UreaCHEBI:16199, CH4N2O, cytosol

Catalysed by

arginase activity of ARG1 trimer [cytosol]EC 3.5.3.1

Literature

Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response Proc Natl Acad Sci U S A, 2005
Molecular basis of phenotypic variation in patients with argininemia Hum Genet, 1995