Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

glutamate + acetyl CoA => N-acetyl glutamate + CoA

Ac-CoA + L-Glu → CoA-SH + NAcGlu + H+

Reactome: R-HSA-70542
Compartment: mitochondrial matrix
Rhea: RHEA:24293

Inputs

Ac-CoACHEBI:57288, C23H34N7O17P3S, mitochondrial matrix
L-GluCHEBI:29985, C5H8NO4, mitochondrial matrix

Outputs

CoA-SHCHEBI:57287, C21H32N7O16P3S, mitochondrial matrix
NAcGluCHEBI:44337, C7H9NO5, mitochondrial matrix
H+CHEBI:15378, H, mitochondrial matrix

Catalysed by

L-glutamate N-acetyltransferase activity, acting on acetyl-CoA as donor of NAGS(19-534) dimer [mitochondrial matrix]EC 2.3.1.1

Literature

Cloning and expression of the human N-acetylglutamate synthase gene. Biochem Biophys Res Commun, 2002
Mammalian N-acetylglutamate synthase Mol Genet Metab, 2004