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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NUDT12 hydrolyses NADH to NMNH

NADH + H2O → NMNH + 2 H+ + AMP

Reactome: R-HSA-6809287
Compartment: peroxisomal matrix
Rhea: RHEA:48869

Inputs

NADHCHEBI:57945, C21H27N7O14P2, peroxisomal matrix
H2OCHEBI:15377, H2O, peroxisomal matrix

Outputs

NMNHCHEBI:90832, C11H15N2O8P, peroxisomal matrix
2 H+CHEBI:15378, H, peroxisomal matrix
AMPCHEBI:456215, C10H12N5O7P, peroxisomal matrix

Catalysed by

NADH pyrophosphatase activity of NUDT12 [peroxisomal matrix]EC 3.6.1.22; UniProt Q9BQG2

Literature

Mammalian NADH diphosphatases of the Nudix family: cloning and characterization of the human peroxisomal NUDT12 protein Biochem. J., 2003