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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
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Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
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Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

CARKD dehydrates S-NAD(P)HX to NADPH

S-NADPHX + ATP → NADPH + ADP + Pi + 3 H+

Reactome: R-HSA-6806967
Compartment: mitochondrial matrix
Rhea: RHEA:32232

Inputs

S-NADPHXCHEBI:64074, C21H29N7O15P2, mitochondrial matrix
ATPCHEBI:30616, C10H12N5O13P3, mitochondrial matrix

Outputs

NADPHCHEBI:57783, C21H26N7O17P3, mitochondrial matrix
ADPCHEBI:456216, C10H12N5O10P2, mitochondrial matrix
PiCHEBI:43474, HO4P, mitochondrial matrix
3 H+CHEBI:15378, H, mitochondrial matrix

Catalysed by

ATP-dependent NAD(P)H-hydrate dehydratase activity of CARKD [mitochondrial matrix]EC 4.2.1.93; UniProt Q8IW45

Literature

Extremely conserved ATP- or ADP-dependent enzymatic system for nicotinamide nucleotide repair J. Biol. Chem., 2011