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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man

alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc + H2O → GlcNAc:Man + 2 Man

Reactome: R-HSA-6799581
Compartment: lysosomal lumen
Rhea: None recorded

Inputs

alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcCHEBI:91279, C26H45NO21, lysosomal lumen
H2OCHEBI:15377, H2O, lysosomal lumen

Outputs

GlcNAc:ManCHEBI:71553, C14H25NO11, lysosomal lumen
2 ManCHEBI:4208, C6H12O6, lysosomal lumen

Catalysed by

mannan endo-1,6-alpha-mannosidase activity of MAN2B2:Zn2+ [lysosomal lumen]EC 3.2.1.101

Literature

Human lysosomal alpha-mannosidases exhibit different inhibition and metal binding properties Protein Sci., 2009
Characterization of a human core-specific lysosomal {alpha}1,6-mannosidase involved in N-glycan catabolism J. Biol. Chem., 2005