MAN2C1 hydrolyses GlcNAc (Man)9 to GlcNAc (Man)5
alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-bet… + 4 H2O → alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc + 4 Man
- Reactome
- R-HSA-6799545
- Compartment
- cytosol
- Rhea
- None recorded
Inputs
- alpha-D-Man-(1->2)-alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->3)-[alpha-D-Man-(1->2)-alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-bet…CHEBI:91284, C62H105NO51, cytosol
- 4 H2OCHEBI:15377, H2O, cytosol
Outputs
- alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAcCHEBI:91280, C38H65NO31, cytosol
- 4 ManCHEBI:4208, C6H12O6, cytosol
Catalysed by
- alpha-mannosidase activity of MAN2C1:Zn2+ [cytosol]EC 3.2.1.24