UGT8 transfers Gal from UDP-Gal to CERA
CERA + UDP-Gal → GalCer + UDP + H+
- Reactome
- R-HSA-6785933
- Compartment
- cytosol · endoplasmic reticulum membrane
- Rhea
- RHEA:48344
Inputs
- CERACHEBI:83273, C4H7NO3R2, endoplasmic reticulum membrane
- UDP-GalCHEBI:66914, C15H22N2O17P2, endoplasmic reticulum lumen
Outputs
- GalCerCHEBI:36498, C10H17NO8R2, endoplasmic reticulum membrane
- UDPCHEBI:58223, C9H11N2O12P2, endoplasmic reticulum lumen
- H+CHEBI:15378, H, endoplasmic reticulum lumen
Catalysed by
- N-acylsphingosine galactosyltransferase activity of UGT8 [endoplasmic reticulum membrane]EC 2.4.1.47; UniProt Q16880
Literature
- Cloning, characterization, and expression of human ceramide galactosyltransferase cDNA Biochem. Biophys. Res. Commun., 1997
- Ceramide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance Adv. Cancer Res., 2013
- UDP-galactose:ceramide galactosyltransferase is a class I integral membrane protein of the endoplasmic reticulum J Biol Chem, 1998