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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

FA2H hydroxylates 1,2-saturated fatty acids

O2 + 2-saturated fatty acid + 2 CYB5B:Fe2+ + 2 H+ → H2O + 2-OH FA + 2 CYB5B:Fe3+

Reactome: R-HSA-5693761
Compartment: endoplasmic reticulum membrane · cytosol
Rhea: None recorded

Inputs

O2CHEBI:15379, O2, cytosol
2-saturated fatty acidCHEBI:83955, C2H2O2R, cytosol
2 CYB5B:Fe2+R-HSA-9842697, endoplasmic reticulum membrane
2 H+CHEBI:15378, H, cytosol

Outputs

H2OCHEBI:15377, H2O, cytosol
2-OH FACHEBI:76177, C2H2O3R, cytosol
2 CYB5B:Fe3+R-HSA-9842694, endoplasmic reticulum membrane

Catalysed by

fatty acid 2-hydroxylase activity of FA2H [endoplasmic reticulum membrane]UniProt Q7L5A8

Literature

The human FA2H gene encodes a fatty acid 2-hydroxylase J. Biol. Chem., 2004
Fatty acid 2-hydroxylase, encoded by FA2H, accounts for differentiation-associated increase in 2-OH ceramides during keratinocyte differentiation J. Biol. Chem., 2007
Fatty acid 2-Hydroxylation in mammalian sphingolipid biology Biochim Biophys Acta, 2010
Fatty Acid 2-Hydroxylase and 2-Hydroxylated Sphingolipids: Metabolism and Function in Health and Diseases Int J Mol Sci, 2023
Stereospecificity of fatty acid 2-hydroxylase and differential functions of 2-hydroxy fatty acid enantiomers J Lipid Res, 2012