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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PPM1K dephosphorylates p-BCKDH

p-BCKDH + 2 H2O → BCKDH + 2 Pi

Reactome: R-HSA-5693153
Compartment: mitochondrial matrix
Rhea: RHEA:77248

Inputs

p-BCKDHR-HSA-5693120, mitochondrial matrix
2 H2OCHEBI:15377, H2O, mitochondrial matrix

Outputs

BCKDHR-HSA-70019, mitochondrial matrix
2 PiCHEBI:43474, HO4P, mitochondrial matrix

Catalysed by

[3-methyl-2-oxobutanoate dehydrogenase (lipoamide)]-phosphatase activity of PPM1K:Mn2+ [mitochondrial matrix]EC 3.1.3.52

Literature

Structural and biochemical characterization of human mitochondrial branched-chain α-ketoacid dehydrogenase phosphatase J. Biol. Chem., 2012