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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ALDH3A2-1 oxidises HD2NAL to PALM

H2O + HD2NAL + NAD+ → H+ + NADH + PALM

Reactome: R-HSA-5692261
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

H2OCHEBI:15377, H2O, cytosol
HD2NALCHEBI:17585, C16H30O, cytosol
NAD+CHEBI:57540, C21H26N7O14P2, cytosol

Outputs

H+CHEBI:15378, H, cytosol
NADHCHEBI:57945, C21H27N7O14P2, cytosol
PALMCHEBI:7896, C16H31O2, cytosol

Catalysed by

aldehyde dehydrogenase (NAD+) activity of ALDH3A2-1 dimer [endoplasmic reticulum membrane]EC 1.2.1.3

Literature

Dual subcellular localization in the endoplasmic reticulum and peroxisomes and a vital role in protecting against oxidative stress of fatty aldehyde dehydrogenase are achieved by alternative splicing J. Biol. Chem., 2007
Sjögren-Larsson syndrome is caused by mutations in the fatty aldehyde dehydrogenase gene Nat. Genet., 1996
Monitoring of fatty aldehyde dehydrogenase by formation of pyrenedecanoic acid from pyrenedecanal J. Lipid Res., 2010
Human liver fatty aldehyde dehydrogenase: microsomal localization, purification, and biochemical characterization Biochim. Biophys. Acta, 1997
The Sjögren-Larsson syndrome gene encodes a hexadecenal dehydrogenase of the sphingosine 1-phosphate degradation pathway Mol. Cell, 2012
Fatty aldehyde dehydrogenase: genomic structure, expression and mutation analysis in Sjögren-Larsson syndrome Chem. Biol. Interact., 2001