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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ACO1:4Fe-4S isomerises CIT to ISCIT

CIT → ISCIT

Reactome: R-HSA-5690911
Compartment: cytosol
Rhea: RHEA:10337

Inputs

CITCHEBI:16947, C6H5O7, cytosol

Outputs

ISCITCHEBI:15562, C6H5O7, cytosol

Catalysed by

aconitate hydratase activity of ACO1:4Fe-4S [cytosol]EC 4.2.1.3

Literature

A regulated RNA binding protein also possesses aconitase activity Proc. Natl. Acad. Sci. U.S.A., 1991
The bifunctional iron-responsive element binding protein/cytosolic aconitase: the role of active-site residues in ligand binding and regulation Proc. Natl. Acad. Sci. U.S.A., 1994
Crystal structure of human iron regulatory protein 1 as cytosolic aconitase Structure, 2006
Cytosolic aconitase activity sustains adipogenic capacity of adipose tissue connecting iron metabolism and adipogenesis FASEB J, 2015