Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

NNMT transfers CH3 from SAM to NAM to form MNA

NAM + AdoMet → AdoHcy + MNA

Reactome: R-HSA-5359451
Compartment: cytosol
Rhea: RHEA:23885

Inputs

NAMCHEBI:17154, C6H6N2O, cytosol
AdoMetCHEBI:59789, C15H23N6O5S, cytosol

Outputs

AdoHcyCHEBI:57856, C14H20N6O5S, cytosol
MNACHEBI:16797, C7H9N2O, cytosol

Catalysed by

nicotinamide N-methyltransferase activity of NNMT [cytosol]EC 2.1.1.1; UniProt P40261

NNMT transfers CH3 from SAM to NAM to form MNA

Inputs

Outputs

Catalysed by

Literature