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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

a-ketoisocaproate, a-keto-b-methylvalerate, or a-ketoisovalerate + glutamate leu, ile, or val + alpha-ketoglutarate [BCAT1]

KIC,KMVA,KIV + L-Glu → Leu, Ile, Val + 2OG

Reactome: R-HSA-508189
Compartment: cytosol
Rhea: RHEA:18323, RHEA:24803, RHEA:24815

Inputs

KIC,KMVA,KIVR-ALL-508187, cytosol
L-GluCHEBI:29985, C5H8NO4, cytosol

Outputs

Leu, Ile, ValR-ALL-508182, cytosol
2OGCHEBI:16810, C5H4O5, cytosol

Catalysed by

branched-chain-amino-acid:2-oxoglutarate transaminase activity of BCAT1 dimer [cytosol]EC 2.6.1.42

Literature

Structural determinants for branched-chain aminotransferase isozyme-specific inhibition by the anticonvulsant drug gabapentin J Biol Chem, 2005