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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

poly((1,4)-alpha-glycosyl) glycogenin-1 + n orthophosphate => glycogenin-1 + n D-glucose 1-phosphate [PYGM,PYGB]

poly((1,4)-alpha-glucosyl)GYG1 dimer + Pi → GYG1 dimer + G1P

Reactome: R-HSA-453358
Compartment: cytosol
Rhea: RHEA:41733

Inputs

poly((1,4)-alpha-glucosyl)GYG1 dimerR-HSA-453217, cytosol
PiCHEBI:43474, HO4P, cytosol

Outputs

GYG1 dimerR-HSA-70203, cytosol
G1PCHEBI:58601, C6H11O9P, cytosol

Catalysed by

glycogen phosphorylase activity of active PYGM and PYGB dimers [cytosol]EC 2.4.1.1

Literature

Activation of human liver glycogen phosphorylase by alteration of the secondary structure and packing of the catalytic core Mol Cell, 2000
The family of glycogen phosphorylases: structure and function Crit Rev Biochem Mol Biol, 1989