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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PYGB dimer, b form + 2 AMP => PYGB b dimer:AMP complex

PYGB dimer b form + 2 AMP → PYGB b dimer:AMP

Reactome: R-HSA-453356
Compartment: cytosol
Rhea: None recorded

Inputs

PYGB dimer b formR-HSA-71863, cytosol
2 AMPCHEBI:456215, C10H12N5O7P, cytosol

Outputs

PYGB b dimer:AMPR-HSA-453332, cytosol

Catalysed by

AMP binding activity of PYGB dimer b form [cytosol]

Literature

Activation of human liver glycogen phosphorylase by alteration of the secondary structure and packing of the catalytic core Mol Cell, 2000
The family of glycogen phosphorylases: structure and function Crit Rev Biochem Mol Biol, 1989