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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

glycogen phosphorylase (PYGB) dimer b + 2 ATP => glycogen phosphorylase (PYGB) dimer a + 2 ADP

PYGB dimer b form + 2 ATP → PYGB dimer a form + 2 ADP + 2 H+

Reactome: R-HSA-453337
Compartment: cytosol
Rhea: RHEA:17990

Inputs

PYGB dimer b formR-HSA-71863, cytosol
2 ATPCHEBI:30616, C10H12N5O13P3, cytosol

Outputs

PYGB dimer a formR-HSA-71869, cytosol
2 ADPCHEBI:456216, C10H12N5O10P2, cytosol
2 H+CHEBI:15378, H, cytosol

Catalysed by

phosphorylase kinase activity of phosphorylase kinase complex (PHKM) [cytosol]EC 2.7.11.19

Literature

The family of glycogen phosphorylases: structure and function Crit Rev Biochem Mol Biol, 1989