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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

arginine + H2O => ornithine + urea [ARG2]

L-Arg + H2O → L-Orn + Urea

Reactome: R-HSA-452036
Compartment: mitochondrial matrix
Rhea: RHEA:20570

Inputs

L-ArgCHEBI:32682, C6H15N4O2, mitochondrial matrix
H2OCHEBI:15377, H2O, mitochondrial matrix

Outputs

L-OrnCHEBI:46911, C5H13N2O2, mitochondrial matrix
UreaCHEBI:16199, CH4N2O, mitochondrial matrix

Catalysed by

arginase activity of ARG2 trimer [mitochondrial matrix]EC 3.5.3.1

Literature

Human arginase II: crystal structure and physiological role in male and female sexual arousal Biochemistry, 2003
Molecular cloning of cDNA for nonhepatic mitochondrial arginase (arginase II) and comparison of its induction with nitric oxide synthase in a murine macrophage-like cell line FEBS Lett, 1996
The human arginases and arginase deficiency J Inherit Metab Dis, 1998