IDH2 dimer decarboxylates isocitrate
ISCIT + NADP+ → 2OG + CO2 + NADPH
- Reactome
- R-HSA-450984
- Compartment
- mitochondrial matrix
- Rhea
- RHEA:19630, RHEA:19629
Inputs
- ISCITCHEBI:15562, C6H5O7, mitochondrial matrix
- NADP+CHEBI:58349, C21H25N7O17P3, mitochondrial matrix
Outputs
- 2OGCHEBI:16810, C5H4O5, mitochondrial matrix
- CO2CHEBI:16526, CO2, mitochondrial matrix
- NADPHCHEBI:57783, C21H26N7O17P3, mitochondrial matrix
Catalysed by
- isocitrate dehydrogenase (NADP+) activity of IDH2 dimer [mitochondrial matrix]EC 1.1.1.42
Literature
- Crystal structure of porcine mitochondrial NADP+-dependent isocitrate dehydrogenase complexed with Mn2+ and isocitrate. Insights into the enzyme mechanism J Biol Chem, 2002
- Insights from retinitis pigmentosa into the roles of isocitrate dehydrogenases in the Krebs cycle Nat Genet, 2008
- Di- and triphosphopyridine nucleotide isocitric dehydrogenases in yeast J Biol Chem, 1951
- Biosynthesis of tricarboxylic acids by carbon dioxide fixation; enzymatic mechanisms J Biol Chem, 1948
- Control of mitochondrial redox balance and cellular defense against oxidative damage by mitochondrial NADP+-dependent isocitrate dehydrogenase J Biol Chem, 2001
- IDH2 mutations in patients with D-2-hydroxyglutaric aciduria Science, 2010