NNT dimer transfers proton from NADPH to NAD+
NAD+ + NADPH + H+ → H+ + NADH + NADP+
- Reactome
- R-HSA-450971
- Compartment
- mitochondrion
- Rhea
- RHEA:47992
Inputs
- NAD+CHEBI:57540, C21H26N7O14P2, mitochondrial matrix
- NADPHCHEBI:57783, C21H26N7O17P3, mitochondrial matrix
- H+CHEBI:15378, H, mitochondrial intermembrane space
Outputs
- H+CHEBI:15378, H, mitochondrial matrix
- NADHCHEBI:57945, C21H27N7O14P2, mitochondrial matrix
- NADP+CHEBI:58349, C21H25N7O17P3, mitochondrial matrix
Catalysed by
- NAD(P)+ transhydrogenase (Si-specific) activity of NNT dimer [mitochondrial inner membrane]EC 1.6.1.1
Literature
- The high-resolution structure of the NADP(H)-binding component (dIII) of proton-translocating transhydrogenase from human heart mitochondria Structure, 2000
- Mitochondrial energy-linked nicotinamide nucleotide transhydrogenase. Membrane topography of the bovine enzyme J Biol Chem, 1991
- Mitochondrial NAD(P) + Transhydrogenase: From Molecular Features to Physiology and Disease Antioxid Redox Signal, 2022
- The cDNA sequence of proton-pumping nicotinamide nucleotide transhydrogenase from man and mouse Biochim Biophys Acta, 1996
- Structure and mechanism of mitochondrial proton-translocating transhydrogenase Nature, 2019