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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SGMS1 transfers phosphocholine onto ceramide

PC + CERA → SPHM + DAG

Reactome: R-HSA-429798
Compartment: Golgi membrane
Rhea: RHEA:81452

Inputs

PCCHEBI:57643, C10H18NO8PR2, Golgi membrane
CERACHEBI:83273, C4H7NO3R2, Golgi membrane

Outputs

SPHMCHEBI:64583, C9H19N2O6PR2, Golgi membrane
DAGCHEBI:17815, C5H6O5R2, Golgi membrane

Catalysed by

sphingomyelin synthase activity of SGMS1 [Golgi membrane]EC 2.7.8.27; UniProt Q86VZ5

Literature

Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells J Biol Chem, 2007
Expression cloning of a human cDNA restoring sphingomyelin synthesis and cell growth in sphingomyelin synthase-defective lymphoid cells J Biol Chem, 2004
Identification of a family of animal sphingomyelin synthases EMBO J, 2004
Evidence for a new biosynthetic pathway of sphingomyelin in SV 40 transformed mouse cells Biochem Biophys Res Commun, 1972
The enzymatic formation of sphingomyelin from ceramide and lecithin in mouse liver J Biol Chem, 1974
The sphingomyelin synthase family: proteins, diseases, and inhibitors Biol Chem, 2017