SGMS2 transfers phosphocholine onto ceramide
PC + CERA → SPHM + DAG
- Reactome
- R-HSA-429786
- Compartment
- plasma membrane
- Rhea
- RHEA:81452
Inputs
- PCCHEBI:57643, C10H18NO8PR2, plasma membrane
- CERACHEBI:83273, C4H7NO3R2, plasma membrane
Outputs
- SPHMCHEBI:64583, C9H19N2O6PR2, plasma membrane
- DAGCHEBI:17815, C5H6O5R2, plasma membrane
Catalysed by
- sphingomyelin synthase activity of 2xPalmC-SGMS2 [plasma membrane]EC 2.7.8.27; UniProt Q8NHU3
Literature
- Both sphingomyelin synthases SMS1 and SMS2 are required for sphingomyelin homeostasis and growth in human HeLa cells J Biol Chem, 2007
- Identification of a family of animal sphingomyelin synthases EMBO J, 2004
- Sphingomyelin synthase 2 is palmitoylated at the COOH-terminal tail, which is involved in its localization in plasma membranes Biochem Biophys Res Commun, 2009
- Evidence for a new biosynthetic pathway of sphingomyelin in SV 40 transformed mouse cells Biochem Biophys Res Commun, 1972
- The enzymatic formation of sphingomyelin from ceramide and lecithin in mouse liver J Biol Chem, 1974
- SMS overexpression and knockdown: impact on cellular sphingomyelin and diacylglycerol metabolism, and cell apoptosis J Lipid Res, 2008