SLC5A8 (SMCT) co-transports monocarboxylates and Na+ from extracellular region to cytosol

monocarboxylates transported by SLC5A8 + 2 Na+ → monocarboxylates transported by SLC5A8 + 2 Na+

Reactome

R-HSA-429749

Compartment

plasma membrane · cytosol · extracellular region

Rhea

RHEA:75803, RHEA:75791, RHEA:75799, RHEA:75807, RHEA:27814, RHEA:72935, RHEA:75795, RHEA:72947, RHEA:72951, RHEA:72939, RHEA:72943, RHEA:72955

Catalysed by

• monocarboxylic acid transmembrane transporter activity of SLC5A8 [plasma membrane]UniProt Q8N695

Literature

1. The human tumour suppressor gene SLC5A8 expresses a Na+-monocarboxylate cotransporter J Physiol, 2004
2. NAD + metabolism and its roles in cellular processes during ageing Nat Rev Mol Cell Biol, 2021
3. Functional identification of SLC5A8, a tumor suppressor down-regulated in colon cancer, as a Na(+)-coupled transporter for short-chain fatty acids J Biol Chem, 2004