Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PPM1L dephosphorylates multiphospho-CERT1-2

3 H2O + PPM1L:VAPA/B dimer + p-S,S132,T-CERT1-2 → CERT1-2:PPM1L:VAPA/B dimer + 3 Pi

Reactome: R-HSA-429730
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:20630, RHEA:47005

Inputs

3 H2OCHEBI:15377, H2O, cytosol
PPM1L:VAPA/B dimerR-HSA-429703, endoplasmic reticulum membrane
p-S,S132,T-CERT1-2R-HSA-429695, cytosol

Outputs

CERT1-2:PPM1L:VAPA/B dimerR-HSA-429672, endoplasmic reticulum membrane
3 PiCHEBI:43474, HO4P, cytosol

Catalysed by

protein serine/threonine phosphatase activity of PPM1L:VAPA/B dimer [endoplasmic reticulum membrane]EC 3.1.3.16

PPM1L dephosphorylates multiphospho-CERT1-2

Inputs

Outputs

Catalysed by

Literature