PRKD1,2,3 phosphorylates CERT1-2
ATP + CERT1-2 → ADP + p-S132-CERT1-2 + H+
- Reactome
- R-HSA-429698
- Compartment
- cytosol
- Rhea
- None recorded
Inputs
- ATPCHEBI:30616, C10H12N5O13P3, cytosol
- CERT1-2R-HSA-429712, cytosol
Outputs
- ADPCHEBI:456216, C10H12N5O10P2, cytosol
- p-S132-CERT1-2R-HSA-429704, cytosol
- H+CHEBI:15378, H, cytosol
Catalysed by
- diacylglycerol-dependent, calcium-independent serine/threonine kinase activity of PRKD1,2,3 [cytosol]EC 2.7.11.13
Literature
- Regulation of secretory transport by protein kinase D-mediated phosphorylation of the ceramide transfer protein J Cell Biol, 2007
- Hyperosmotic Stress Induces Phosphorylation of CERT and Enhances Its Tethering throughout the Endoplasmic Reticulum Int J Mol Sci, 2022
- Structure, functions and regulation of CERT, a lipid-transfer protein for the delivery of ceramide at the ER-Golgi membrane contact sites FEBS Lett, 2019
- Phosphoregulation of the ceramide transport protein CERT at serine 315 in the interaction with VAMP-associated protein (VAP) for inter-organelle trafficking of ceramide in mammalian cells J Biol Chem, 2014
- Integration of non-vesicular and vesicular transport processes at the Golgi complex by the PKD-CERT network Biochim Biophys Acta, 2012