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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PLPP1,2,3 dephosphorylate cytosolic sphingosine-1-phosphate

H2O + C18-S1P → Pi + sphingosine

Reactome: R-HSA-428696
Compartment: cytosol · plasma membrane
Rhea: RHEA:27518

Inputs

H2OCHEBI:15377, H2O, cytosol
C18-S1PCHEBI:60119, C18H37NO5P, cytosol

Outputs

PiCHEBI:43474, HO4P, cytosol
sphingosineCHEBI:57756, C18H38NO2, cytoplasm

Catalysed by

sphingosine-1-phosphate phosphatase activity of PLPP1,2,3 [plasma membrane]

Literature

Human type 2 phosphatidic acid phosphohydrolases. Substrate specificity of the type 2a, 2b, and 2c enzymes and cell surface activity of the 2a isoform. J Biol Chem, 1998
Lipid phosphate phosphatases and their roles in mammalian physiology and pathology J Lipid Res, 2015
Lipid Phosphate Phosphatases and Cancer Biomolecules, 2020