Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

PLPP1 dephosphorylates extracellular sphingosine-1-phosphate

H2O + C18-S1P → Pi + sphingosine

Reactome: R-HSA-428690
Compartment: extracellular region · plasma membrane
Rhea: RHEA:27518

Inputs

H2OCHEBI:15377, H2O, extracellular region
C18-S1PCHEBI:60119, C18H37NO5P, extracellular region

Outputs

PiCHEBI:43474, HO4P, extracellular region
sphingosineCHEBI:57756, C18H38NO2, cytoplasm

Catalysed by

sphingosine-1-phosphate phosphatase activity of PLPP1 [plasma membrane]UniProt O14494

PLPP1 dephosphorylates extracellular sphingosine-1-phosphate

Inputs

Outputs

Catalysed by

Literature