PXLP-SGPL1 cleaves sphingoid-1-phosphates
S1P,SPAP → PETA + HXAL,HD2NAL
- Reactome
- R-HSA-428681
- Compartment
- cytosol · endoplasmic reticulum membrane
- Rhea
- RHEA:18594, RHEA:33508
Inputs
- S1P,SPAPR-ALL-9844328, cytosol
Outputs
- PETACHEBI:17553, C2H8NO4P, cytosol
- HXAL,HD2NALR-ALL-9844327, cytosol
Catalysed by
- sphinganine-1-phosphate aldolase activity of PXLP-SGPL1 [endoplasmic reticulum membrane]EC 4.1.2.27; UniProt O95470
Literature
- Human sphingosine-1-phosphate lyase: cDNA cloning, functional expression studies and mapping to chromosome 10q22(1) Biochim Biophys Acta, 2000
- Sphingosine-1-phosphate lyase in development and disease: sphingolipid metabolism takes flight Biochim Biophys Acta, 2008
- Nephrotic syndrome and adrenal insufficiency caused by a variant in SGPL1 Clin Kidney J, 2018
- Fifty years of lyase and a moment of truth: sphingosine phosphate lyase from discovery to disease J Lipid Res, 2019