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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SGPP1,2 dephosphorylate sphingoid-1-phosphates

H2O + S1P → Pi + SPG

Reactome: R-HSA-428664
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:63952

Inputs

H2OCHEBI:15377, H2O, cytosol
S1PCHEBI:76941, C3H8NO5PR, cytoplasm

Outputs

PiCHEBI:43474, HO4P, cytosol
SPGCHEBI:84410, C3H9NO2R, cytosol

Catalysed by

sphingosine-1-phosphate phosphatase activity of SGPP [endoplasmic reticulum membrane]

SGPP1,2 dephosphorylate sphingoid-1-phosphates

Inputs

Outputs

Catalysed by

Literature