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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SPHK1 phosphorylates sphingoid

ATP + SPG → ADP + S1P + H+

Reactome: R-HSA-428273
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:51496

Inputs

ATPCHEBI:30616, C10H12N5O13P3, cytosol
SPGCHEBI:84410, C3H9NO2R, cytosol

Outputs

ADPCHEBI:456216, C10H12N5O10P2, cytosol
S1PCHEBI:76941, C3H8NO5PR, cytoplasm
H+CHEBI:15378, H, cytosol

Catalysed by

lipid kinase activity of SPHK1 [cytosol]UniProt Q9NYA1

Literature

Functional characterization of human sphingosine kinase-1 FEBS Lett, 2000
Human sphingosine kinase: purification, molecular cloning and characterization of the native and recombinant enzymes Biochem J, 2000
Mammalian sphingosine kinase (SphK) isoenzymes and isoform expression: challenges for SphK as an oncotarget Oncotarget, 2017
Molecular basis of sphingosine kinase 1 substrate recognition and catalysis Structure, 2013
The compartmentalization and translocation of the sphingosine kinases: mechanisms and functions in cell signaling and sphingolipid metabolism Crit Rev Biochem Mol Biol, 2011
Transcriptional Regulation of Sphingosine Kinase 1 Cells, 2020