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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ACER3 hydrolyzes phytoceramide

H2O + phytoceramide-C16 → phytosphingosine + RCOO-

Reactome: R-HSA-428262
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: RHEA:33555

Inputs

H2OCHEBI:15377, H2O, cytosol
phytoceramide-C16CHEBI:31998, C19H38NO4R, endoplasmic reticulum membrane

Outputs

phytosphingosineCHEBI:64124, C18H40NO3, cytosol
RCOO-CHEBI:28868, CO2R, cytosol

Catalysed by

N-acylsphingosine amidohydrolase activity of ACER3:Ca2+:Zn2+ [endoplasmic reticulum membrane]EC 3.5.1.23

Literature

Cloning and characterization of a novel human alkaline ceramidase. A mammalian enzyme that hydrolyzes phytoceramide J Biol Chem, 2001
Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate Biochim Biophys Acta, 2008
Elusive Roles of the Different Ceramidases in Human Health, Pathophysiology, and Tissue Regeneration Cells, 2020
Role of Ceramidases in Sphingolipid Metabolism and Human Diseases Cells, 2019
Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy Nat Commun, 2018
Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols J Lipid Res, 2015