Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

DEGS2 oxygenates dihydroceramide

H+ + O2 + DHCE + CYB5B:Fe2+ → H2O + phytoceramide + CYB5B:Fe3+

Reactome: R-HSA-428260
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

H+CHEBI:15378, H, cytosol
O2CHEBI:15379, O2, cytosol
DHCECHEBI:139048, C5H9NO3R2, endoplasmic reticulum membrane
CYB5B:Fe2+R-HSA-9842697, endoplasmic reticulum membrane

Outputs

H2OCHEBI:15377, H2O, cytosol
phytoceramideCHEBI:139051, C5H9NO4R2, endoplasmic reticulum membrane
CYB5B:Fe3+R-HSA-9842694, endoplasmic reticulum membrane

Catalysed by

sphingolipid C4-monooxygenase activity of DEGS2 [endoplasmic reticulum membrane]EC 1.14.18.5; UniProt Q6QHC5

DEGS2 oxygenates dihydroceramide

Inputs

Outputs

Catalysed by

Literature