ACER1 hydrolyzes ceramide (endoplasmic reticulum)
H2O + CERA → RCOO- + SPG
- Reactome
- R-HSA-428231
- Compartment
- cytosol · endoplasmic reticulum membrane
- Rhea
- RHEA:78455
Inputs
- H2OCHEBI:15377, H2O, cytosol
- CERACHEBI:83273, C4H7NO3R2, endoplasmic reticulum membrane
Outputs
- RCOO-CHEBI:28868, CO2R, cytosol
- SPGCHEBI:84410, C3H9NO2R, cytosol
Catalysed by
- N-acylsphingosine amidohydrolase activity of ACER1 [endoplasmic reticulum membrane]EC 3.5.1.23; UniProt Q8TDN7
Literature
- Upregulation of the human alkaline ceramidase 1 and acid ceramidase mediates calcium-induced differentiation of epidermal keratinocytes J Invest Dermatol, 2008
- Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate Biochim Biophys Acta, 2008
- Elusive Roles of the Different Ceramidases in Human Health, Pathophysiology, and Tissue Regeneration Cells, 2020
- Role of Ceramidases in Sphingolipid Metabolism and Human Diseases Cells, 2019
- Activity of neutral and alkaline ceramidases on fluorogenic N-acylated coumarin-containing aminodiols J Lipid Res, 2015
- Alkaline ceramidase 1 is essential for mammalian skin homeostasis and regulating whole-body energy expenditure J Pathol, 2016