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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

ACER2 hydrolyzes ceramide (Golgi)

H2O + CERA → RCOO- + SPG

Reactome: R-HSA-428205
Compartment: Golgi membrane · cytosol
Rhea: RHEA:78455

Inputs

H2OCHEBI:15377, H2O, cytosol
CERACHEBI:83273, C4H7NO3R2, Golgi membrane

Outputs

RCOO-CHEBI:28868, CO2R, cytosol
SPGCHEBI:84410, C3H9NO2R, cytosol

Catalysed by

N-acylsphingosine amidohydrolase activity of ACER2 [Golgi membrane]EC 3.5.1.23; UniProt Q5QJU3

Literature

Golgi alkaline ceramidase regulates cell proliferation and survival by controlling levels of sphingosine and S1P FASEB J, 2006
Ceramidases: regulators of cellular responses mediated by ceramide, sphingosine, and sphingosine-1-phosphate Biochim Biophys Acta, 2008
Elusive Roles of the Different Ceramidases in Human Health, Pathophysiology, and Tissue Regeneration Cells, 2020
Role of Ceramidases in Sphingolipid Metabolism and Human Diseases Cells, 2019
Substrate specificity, membrane topology, and activity regulation of human alkaline ceramidase 2 (ACER2) J Biol Chem, 2010
Tumor suppressor p53 links ceramide metabolism to DNA damage response through alkaline ceramidase 2 Cell Death Differ, 2018