Skip to content

DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Ceramide synthases transfer acyl-CoA onto sphingoid

acyl-CoA + sphingoid base → DHCE + CoA-SH + H+

Reactome: R-HSA-428185
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

acyl-CoACHEBI:58342, C22H31N7O17P3SR, cytosol
sphingoid baseCHEBI:35785, cytoplasm

Outputs

DHCECHEBI:139048, C5H9NO3R2, endoplasmic reticulum membrane
CoA-SHCHEBI:57287, C21H32N7O16P3S, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

sphingosine N-acyltransferase activity of Ceramide synthases [endoplasmic reticulum membrane]EC 2.3.1.24

Literature

When do Lasses (longevity assurance genes) become CerS (ceramide synthases)?: Insights into the regulation of ceramide synthesis J Biol Chem, 2006
LASS5 is a bona fide dihydroceramide synthase that selectively utilizes palmitoyl-CoA as acyl donor J Biol Chem, 2005
Characterization of ceramide synthase 2: tissue distribution, substrate specificity, and inhibition by sphingosine 1-phosphate J Biol Chem, 2008
Ceramide synthases at the centre of sphingolipid metabolism and biology Biochem J, 2012
Ceramide synthases in biomedical research Chem Phys Lipids, 2016
Ceramide synthases: roles in cell physiology and signaling Adv Exp Med Biol, 2010