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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

KDSR reduces 3-ketosphingoid

H+ + NADPH + 3-ketosphingoid → NADP+ + sphingoid base

Reactome: R-HSA-428123
Compartment: cytosol · endoplasmic reticulum membrane
Rhea: None recorded

Inputs

H+CHEBI:15378, H, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
3-ketosphingoidCHEBI:84411, C3H7NO2R, endoplasmic reticulum membrane

Outputs

NADP+CHEBI:58349, C21H25N7O17P3, cytosol
sphingoid baseCHEBI:35785, cytoplasm

Catalysed by

3-dehydrosphinganine reductase activity of KDSR [endoplasmic reticulum membrane]EC 1.1.1.102; UniProt Q06136

Literature

FVT-1 is a mammalian 3-ketodihydrosphingosine reductase with an active site that faces the cytosolic side of the endoplasmic reticulum membrane J Biol Chem, 2004
Mutations in KDSR Cause Recessive Progressive Symmetric Erythrokeratoderma Am J Hum Genet, 2017