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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

Data

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

SLC26A1,2 cotransport SO4(2-), anion from extracellular region to cytosol

SO4(2-) + SLC26A1,2 cargo → SO4(2-) + SLC26A1,2 cargo

Reactome: R-HSA-427555
Compartment: plasma membrane
Rhea: RHEA:73215, RHEA:72387, RHEA:72275, RHEA:75091

Inputs

SO4(2-)CHEBI:16189, O4S, extracellular region
SLC26A1,2 cargoR-ALL-9941480, cytosol

Outputs

SO4(2-)CHEBI:16189, O4S, cytosol
SLC26A1,2 cargoR-ALL-9941466, extracellular region

Catalysed by

sulfate transmembrane transporter activity of SLC26A1,2 [plasma membrane]

Literature

Characterization of the human sulfate anion transporter (hsat-1) protein and gene (SAT1; SLC26A1) DNA Cell Biol, 2003
The diastrophic dysplasia gene encodes a novel sulfate transporter: positional cloning by fine-structure linkage disequilibrium mapping Cell, 1994
The SLC26 gene family of anion transporters and channels Mol. Aspects Med., 2013
Functional expression cloning of the canalicular sulfate transport system of rat hepatocytes J Biol Chem, 1994
The SLC26 gene family of multifunctional anion exchangers Pflugers Arch, 2004
Mutations in the diastrophic dysplasia sulfate transporter (DTDST) gene (SLC26A2): 22 novel mutations, mutation review, associated skeletal phenotypes, and diagnostic relevance Hum Mutat, 2001