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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Mitochondrial BTD hydrolyses BCTN

BCTN → Btn + L-Lys

Reactome: R-HSA-4167509
Compartment: mitochondrial matrix
Rhea: RHEA:77172

Inputs

BCTNCHEBI:195545, C16H28N4O4S, mitochondrial matrix

Outputs

BtnCHEBI:15956, C10H16N2O3S, mitochondrial matrix
L-LysCHEBI:32551, C6H15N2O2, mitochondrial matrix

Catalysed by

biotinidase activity of BTD [mitochondrial matrix]EC 3.5.1.12; UniProt P43251

Literature

Human serum biotinidase. cDNA cloning, sequence, and characterization J. Biol. Chem., 1994
Biotinidase deficiency: the enzymatic defect in late-onset multiple carboxylase deficiency Clin. Chim. Acta, 1983
Evolutionary conservation of biotinidase: implications for the enzyme's structure and subcellular localization Mol. Genet. Metab., 2005