Loading the map…

Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

Exchange of isocitrate and 2-oxoglutarate across the peroxisomal membrane

2OG + ISCIT → 2OG + ISCIT

Reactome: R-HSA-390347
Compartment: peroxisomal membrane
Rhea: None recorded

Inputs

2OGCHEBI:16810, C5H4O5, peroxisomal matrix
ISCITCHEBI:15562, C6H5O7, cytosol

Outputs

2OGCHEBI:16810, C5H4O5, cytosol
ISCITCHEBI:15562, C6H5O7, peroxisomal matrix

Catalysed by

carboxylic acid transmembrane transporter activity of isocitrate-oxoglutarate transporter [peroxisomal membrane]

Literature

First identification of a 2-ketoglutarate/isocitrate transport system in mammalian peroxisomes and its characterization Biochem Biophys Res Commun, 2006