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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+

ISCIT + NADP+ → 2OG + CO2 + NADPH + H+

Reactome: R-HSA-389550
Compartment: peroxisomal matrix
Rhea: RHEA:19630

Inputs

ISCITCHEBI:15562, C6H5O7, peroxisomal matrix
NADP+CHEBI:58349, C21H25N7O17P3, peroxisomal matrix

Outputs

2OGCHEBI:16810, C5H4O5, peroxisomal matrix
CO2CHEBI:16526, CO2, peroxisomal matrix
NADPHCHEBI:57783, C21H26N7O17P3, peroxisomal matrix
H+CHEBI:15378, H, peroxisomal matrix

Catalysed by

isocitrate dehydrogenase (NADP+) activity of IDH1 dimer [peroxisomal matrix]EC 1.1.1.42

isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+

Inputs

Outputs

Catalysed by

Literature