Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

Territories

Select a territory to bring it forward.

Reading the map

Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+

ISCIT + NADP+ → 2OG + CO2 + NADPH + H+

Reactome: R-HSA-389540
Compartment: cytosol
Rhea: RHEA:19630

Inputs

ISCITCHEBI:15562, C6H5O7, cytosol
NADP+CHEBI:58349, C21H25N7O17P3, cytosol

Outputs

2OGCHEBI:16810, C5H4O5, cytosol
CO2CHEBI:16526, CO2, cytosol
NADPHCHEBI:57783, C21H26N7O17P3, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

isocitrate dehydrogenase (NADP+) activity of IDH1 dimer [cytosol]EC 1.1.1.42

isocitrate + NADP+ => 2-oxoglutarate + CO2 + NADPH + H+

Inputs

Outputs

Catalysed by

Literature