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DraconiticBiochemistryBiomolecules · Catabolism · Biosynthesis · MetabolismMap

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Human metabolism

Reactome's human metabolism drawn as one network. Each molecule has one home node; widely shared molecules also appear as dashed copies in other territories, linked from their details. .

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Metabolite; its structure appears as you zoom in
Reaction, arrow toward the product
Cofactors and co-substrates are written beside the reaction when you zoom in
Dashed ring: a copy of a widely shared molecule or cofactor in another territory or pathway
Compartment transfer of the molecule it is linked to
Binding, release or complex event; its proteins are named in its details
Outline: reactions mostly in the mitochondrion

Arrows follow Reactome's curated reaction direction.

GYS2 catalyzes the incorporation of phosphoglucose into glycogen-GYG2

PPP1R3C:glycogen-GYG2:GYS2-a tetramer + UDP-Glc → PPP1R3C:phosphoglycogen-GYG2:GYS2-a tetramer + UMP + H+

Reactome: R-HSA-3780994
Compartment: cytosol
Rhea: None recorded

Inputs

PPP1R3C:glycogen-GYG2:GYS2-a tetramerR-HSA-3777104, cytosol
UDP-GlcCHEBI:58885, C15H22N2O17P2, cytosol

Outputs

PPP1R3C:phosphoglycogen-GYG2:GYS2-a tetramerR-HSA-3777094, cytosol
UMPCHEBI:57865, C9H11N2O9P, cytosol
H+CHEBI:15378, H, cytosol

Catalysed by

glycogen synthase activity, transferring glucose-1-phosphate of PPP1R3C:glycogen-GYG2:GYS2-a tetramer [cytosol]

Literature

Glycogen phosphomonoester distribution in mouse models of the progressive myoclonic epilepsy, Lafora disease J. Biol. Chem., 2015
Muscle Glycogen Remodeling and Glycogen Phosphate Metabolism following Exhaustive Exercise of Wild Type and Laforin Knockout Mice J. Biol. Chem., 2015
Hyperphosphorylation of glucosyl C6 carbons and altered structure of glycogen in the neurodegenerative epilepsy Lafora disease Cell Metab., 2013
Phosphate incorporation during glycogen synthesis and Lafora disease Cell Metab., 2011
Malin decreases glycogen accumulation by promoting the degradation of protein targeting to glycogen (PTG) J. Biol. Chem., 2008